In their earlier experiments, the scientists had detected connections between neurons from organoids and neurons from the mouse brain, but they could not tell  whether or not the neurons could actually communicate with one and  other. Optogenetics is an extremely clever technique that uses light to  control neurons. By using this technique, the researchers were able to  specifically stimulate the neurons in the organoids by turning on and  off a light. When the light was on, the neurons of the organoids became  electrically active. When they used electrodes to measure the activity  of neurons outside the organoid in another part of the mouse brain, they  were able to detect electrically activated neurons there too, showing  that organoid neurons could signal to host neurons.
By  tagging the transplanted organoid and creating a  glass window in the skull, the group was able  to keep track of where it was in the mouse brain. The first thing they noticed was that compared to organoids kept in a dish, the organoids that had been successfully transplanted into the mouse brain shared more features with a human brain. The normal human brain has a network of cavities, which are filled by cerebrospinal fluid and is also formed up  of distinct layers of neuronal cells, which mature over time. In the  dish, organoids develop a cavity and begin to form different cell layers  like in a real brain, however, the cells that make up the layers do not  fully mature. When the researchers compared the different cell types  present in the implanted organoids vs. those that were formed in a dish,  they detected a higher number of mature neurons and also other cell  types, such as the star-shaped support cells of the brain, called astrocytes, which are not usually found in lab-grown organoids.
The Transparent Corp forum – This forum is an invaluable resource for any brainwave entrainment user or enthusiast.  Most of the feedback is obviously focused on the Transparent Corp software, but with over 20,000+ posts now you can find answers to the whole array of brainwave entrainment questions on there.  (UPDATE: Sadly, the Transparent Corp forum has now been taken offline)
A combination of strokes works well to relieve muscle tension. Try gentle chops with the edge of your hands or tapping with fingers or cupped palms. Put fingertip pressure on muscle knots. Knead across muscles, and try long, light, gliding strokes. You can apply these strokes to any part of the body that falls easily within your reach. For a short session like this, try focusing on your neck and head:
Attention and learning ability has been suggested to improve as a result of beta stimulation protocols. Research has shown that beta waves tend to be deficient among those who have learning disabilities and/or attention deficits. Other research with photic stimulation determined that stimulating 14 Hz and alternating it with 22 Hz over several sessions produced significant GPA improvements.

The exact physiological mechanisms to explain how exercise improves stress have not been delineated. Human and animal research indicates that being physically active improves the way the body handles stress because of changes in the hormone responses, and that exercise affects neurotransmitters in the brain such as dopamine and serotonin that affect mood and behaviors (9,11). In addition to the possible physiological mechanisms, there also is the possibility that exercise serves as a time-out or break from one’s stressors. A study that tested the time-out hypothesis used a protocol that had participants exercise but did not allow a break from stress during the exercise session (5). Participants were college-aged women who reported that studying was their biggest stressor. Self-report of stress and anxiety symptoms was assessed with a standard questionnaire before and after four conditions over 4 days. The conditions were quiet rest, study, exercise, and studying while exercising. These conditions were counterbalanced across participants, and each condition was 40 minutes in duration. The “exercise only” condition had the greatest calming effect (5). When participants were not given a break from their stressor in the “studying while exercising” condition, exercise did not have the same calming effect.
I believe that there is a frequency at which a brain functions, they can vary depending on circadian rhythm or other factors. You can check the various effects on the brain caused by varying frequencies. Check this link -> Binaural beats. When we expose our brain to isochronic/binaural beats, it has a resonating effect on the brain, i.e. the brain starts to alter its frequency in order to synchronise with the tone. Once the specific frequency is achieved, you will have the desired effect (depending on the specific frequency you are trying to induce).
Magic happens with this amazingly deep meditation MP3. Delta stimulation can be very hypnotic, and Sub-Delta (0 – 1 Hz) in particular is theorized to have soothing effects on the limbic system, such as the amygdala and hypothalamus which themselves operate at delta frequencies. These neural structures are associated with emotions, fear, the fight-or-flight response, blood pressure, tension and more. Many people have found success using Delta as an aid in meditation. Using sub-delta to sooth these structures has resulted in amazing success helping health conditions such as fibromyalgia, chronic pain and hypertension (high blood pressure). Its soothing effects on the limbic system may shed some light on this.
Many of the long-term side-effects of menopause are associated with a deficiency in magnesium. These include heart disease, osteoporosis, weakness, weight gain, and feeling cold all the time. When you take a magnesium supplement, it can help relieve many of these problems and help your body balance your hormones. Magnesium can boost your energy by helping to convert the T4 thyroid hormone into the more active and bioavailable T3. It can also help the liver reduce levels of cortisol, adrenaline, and excessive estrogen.

The eyes of the participants were closed and the VFP goggles illuminated in alternative manner; first the right eye, then the left. The rate at which the photic stimulation was conducted ranged between 0.5 Hz and 50 Hz. Of the 50 patients with migraines, 49 considered their headache as having been “helped” by the stimulation and 36 noted that their headache had completely “stopped” from the VFP goggles.
I can understand how a sensitive boy witnessing a slaughter might decide to go vegetarian, but this article gives no clue what motivates people to take that extra step into avoiding wool, honey and dairy. Because factory farming is the most common response I get when I have asked vegans, but why not support artisanal farming, like those cosseted Swiss milk cows that lead happier lives than the farmers?

Additionally, this root may help you lose weight and feel more energetic. Women who take maca find they have a bit more energy and fewer aches and pains. Maca is popularly included in sports drinks and nootropics that help improve athletic performance. Much of the research has been done on men, in regards to athletic performance using maca, but studies have also shown women benefit as much or even more. Finally, it may help you stabilize your emotions. Specific studies have shown that maca can help relieve the symptoms of mild depression and mood swings.


All you need to experiment with binaural beats is a binaural beat audio and a pair of headphones or earbuds. You can easily find audio files of binaural beats online, such as on YouTube, or you can purchase CDs or download audio files directly to your mp3 player or other device. As mentioned earlier, for a binaural beat to work, the two tones have to have frequencies of less than 1000 Hz, and the difference between the two tones can’t be more than 30 Hz.
Ten years prior to the events of Sun and Moon, Anabel was found unconscious on a Poni Island beach by Looker and Nanu, who had just completed a mission for the International Police. She had lost most of her memories, only able to tell them her name, that she came from Hoenn, that she protected a tower there, and that she was a powerful Trainer. After being placed in the care of the International Police, they detected incredible amounts of Ultra Wormhole energy coming from her, implying that she was a Faller who was lost in a wormhole for a significant time. Anabel has never been informed of this, however.

Exercise is one of the best ways to reduce stress. “When you exercise, your body releases endorphins, which are hormones that fight stress,” says Frank Lupin, MS, ATC, PES, a certified athletic trainer and a personal trainer for Coordinated Health in Bethlehem, Pa. “Exercise helps you get your mind off your problems and clears your head,” adds Thomas Plante, PhD, an associate professor of psychology at Santa Clara University in California. Here are eight different kinds of exercise that can heighten energy and provide stress relief.

In the 1980s, a researcher in Japan, Tsuyoshi Inouye described how light stimulation creates synchronization of brain hemispheres. Since then, other researchers have detailed the positive effects of hemispheric synchronization including a 1984 study by researcher Dr. Gene W. Brockopp stating that hemispheric synchronization resulted in improved intellectual functioning as well as improvements in long-term memory, and these effects are cumulative over time.
It's tempting to reach for a cheeseburger when stressed, but go green at lunch instead. "Green leafy vegetables like spinach contain folate, which produces dopamine, a pleasure-inducing brain chemical, helping you keep calm," says Heather Mangieri, RDN, a spokesperson for the Academy of Nutrition and Dietetics. A 2012 study in the Journal of Affective Disorders of 2,800 middle-aged and elderly people and found those who consumed the most folate had a lower risk of depression symptoms than those who took in the least. And, a 2013 study from the University of Otago found that college students tended to feel calmer, happier, and more energetic on days they ate more fruits and veggies. It can be hard to tell which came first—upbeat thoughts or healthy eating—but the researchers found that healthy eating seemed to predict a positive mood the next day.

As strange as it may sound, vocal toning is a special technique that reduces the stress hormones adrenaline and cortisol. Try sneaking off to a quiet place to spend a few minutes toning before a meeting with your boss and see how much more relaxed and focused you feel. It works by exercising the tiny muscles of the inner ear that help you detect the higher frequencies of human speech that impart emotion and tell you what someone is really trying to say. Not only will you feel more relaxed in that meeting, you’ll also be better able to understand what he’s trying to communicate.
It has been both a pleasure and an enlightening experience listening to the Equisync II CDs for the past month. As a 15 year stroke survivor, daily meditation has become a part of my life. Listening to these CDs reminds me of sitting alone in a forest during periods of rain, whether they be light, heavy, or in between. I am able to access my right hemisphere more readily and experience the feeling of nirvana that we all have within us. When I reach this point, my system reminds itself of all the compassion and connectedness we each have.

Because of the way they are created, there may be a positive benefit from listening to binaural beats without considering the brainwave entrainment aspect, but I haven’t seen any research on that. I first discovered brainwave entrainment through binaural beats about 10 years ago now, but they didn’t do anything for me. So I’ve never been a regular user of them. I believe isochronic tones are a more effective way to produce hemispheric synchronisation because they produce a much stronger response in the brain
For many of us, relaxation means zoning out in front of the TV at the end of a stressful day. But this does little to reduce the damaging effects of stress. To effectively combat stress, we need to activate the body’s natural relaxation response. You can do this by practicing relaxation techniques such as deep breathing, meditation, rhythmic exercise, and yoga. Fitting these activities into your life can help reduce everyday stress, boost your energy and mood, and improve your mental and physical health.
Sensorimotor rhythm (SMR) is one final type of brainwave that has been studied. SMR, also known as low beta, is a type of brainwave, which occurs in the sensorimotor cortex, in the 12 to 15 hertz range when that area of the sensorimotor cortex is idle and immobile. The purpose of SMR brainwaves is not well understood, but some neurofeedback practitioners report training to increase SMR brainwaves can be beneficial for people with autism, epilepsy, ADD, insomnia, drug addiction, and as an aide to better manage stress.
First of all thank you for your amazing website, I have a question regarding these matters, I can make both binaural beats and isochronic tones for myself but I doubt for low frequencies states (Theta and Delta) which one is better? Because I searched a lot and saw that binaural beats are better for low frequencies and for high frequencies (Beta Gamma Lambda….) isochronic tones are more effective. Also, for Alpha states some said isochronic and other said binaural.
Just my FIRST session I felt like I successfully achieved a theta state of meditation….I came out of it feeling extraordinarily renewed and with this profound insight of “everything is going to be ok”….this was all from my FIRST session. I cant wait to continue this on a regular basis to see where it leads….one day I hope to achieve the deeper delta states…

Thanks Lorita. There hasn’t been any isochronic tones research that I’m aware of, for anti-aging, fat loss or attracting people, or any significant anecdotal feedback. You could combine positive affirmations or hypnosis scripts with isochronic tones to try and change habits and that could help with fat loss or build confidence to attract people. But it would be the affirmations and hypnosis doing most of the work, the isochronic tones would just be used to help relax the listener and put them in a more suggestible state. I don’t believe isochronic tones can affect those things, without being used in combination with some kind of vocal mental programming.
According to a recent study published in the British journal Heart, slow or meditative music is a proven stress buster, so set your dial to a soothing station during your commute. And, if you're stuck in a traffic jam, sneak in this quick exercise: Grab your steering wheel and clench the muscles in your fingers, arms, shoulders and back. Do this until your muscles begin to tremble (about 45 seconds), then release. You'll produce a wave of relief in your upper neck and arms all the way down to your fingers. Just make sure your foot is on the brake when you let go of the wheel! (FYI: pink noise is the newest tool for reducing stress.)
Adaptogens can greatly increase the effectiveness of some modern drugs, including antibiotics, anxiolytics (anxiety relief), antidepressants, and hypoglycemic agents. They also can reduce, and in some cases eliminate, the side effects of some drugs. They have a proven record of being safe, efficacious, and quite versatile in their treatment of many conditions.
One larger and more recent randomized and controlled trial looked at the use of binaural beats in 291 patients admitted to the emergency department at a hospital. The researchers observed significant decreases in anxiety levels in patients exposed to audio with embedded binaural beats compared to those who listened to audio without binaural beats or no audio at all (headphones only).

Start by kneading the muscles at the back of your neck and shoulders. Make a loose fist and drum swiftly up and down the sides and back of your neck. Next, use your thumbs to work tiny circles around the base of your skull. Slowly massage the rest of your scalp with your fingertips. Then tap your fingers against your scalp, moving from the front to the back and then over the sides.
Regarding split hemisphere isochronic tones. Think of this as two separate isochronic tones tracks playing independently of each other, one playing in one ear and the other one in the opposite ear. Better still, imagine someone playing and recording a drum beat at a rate of 5 taps per second (5Hz – 5 cycles per second). Then a separate recording of a drum beat is made at a rate of 10 taps per second (10 Hz). You then make an audio track where the left ear/channel hears the 5 drum beats recording and the right ear/channel hears the 10 beat recording. With headphones on, each ear can only hear each respective drum beat and not the other. So you are hearing two different beat recordings at the same time, but it’s different in each ear. A split hemisphere isochronic tones track works just the same. You hear two beats at the same time, not two tones as with binaural beats that create a single beat, but two different speeds of beats in each ear. This is what enables you to stimulate and influence each side of the brain with a different frequency of beat. Binaural beats can only stimulate and influence a whole brain effect using a single beat.
People who handle stress well tend to employ what stress experts call an "optimistic explanatory style." They don't beat themselves up when things don't work out in their favor. So instead of using statements that catastrophize an incident, like "I'm a complete failure," they might say to themselves, "I need to work on my backhand." Or they'll transfer blame to an external source. Rather than saying, "I really blew that presentation," it's, "That was a tough group to engage." Replace the word "expect" with "hope." Expectations can only be used for those things over which you have the greatest personal control. You can expect to quench your thirst with a drink of water. You cannot expect to get the job you just interviewed for. You can hope to get it.
This is a brainwave meditation MP3 that will stimulate the Theta state of mind, allowing you to relax DEEPLY. On the surface you will hear a gentle rain and deep string sounds… underneath the MP3 uses a complex protocol which alternates stimulation between the left and right ears, and uses several ramps to reach the target brainwave frequency. It is useful for hyperactive people who have problems relaxing or entering trance like states.
"When you're stressed, there's a battle being fought inside you," Mangieri says. "The antioxidants and phytonutrients found in berries fight in your defense, helping improve your body's response to stress and fight stress-related free radicals." Research has also shown that blueberry eaters experience a boost in natural killer cells, "a type of white blood cell that plays a vital role in immunity, critical for countering stress," says Cynthia Sass, MPH, RD, Health's contributing nutrition editor.
However, you can give yourself all of the nutrition of the produce in a very easy to drink package. This leaves you feeling light and energetic and gives your body a chance to digest the food quickly. It lets your body extract more vitamins and minerals from the juices you’re drinking, and your body’s demand for food goes down. You won’t feel hungry, and you won’t continually be looking for a snack or meal. You’ll just feel the rush of energy and healing properties from the fruits and vegetables.
It is easy to see why religion quickly spread through culture once it emerged. When humans gained the cognitive capacity to reason and plan for the future, they became aware of their own mortality. The realization that oneself and all one’s loved ones will someday die is naturally terrifying, and this existential fear perfectly set the stage for anxiety-reducing ideas, like ones that offer a never-ending afterlife. But religions are complex ideas, and the psychological effects they have on minds go beyond just relieving anxiety.
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