In a 2016 interview, organoid pioneer Madeline Lancaster at the Medical Research Council  Laboratory of Molecular Biology in Cambridge, England said of her 3D  brain tissue structures, “Just to be clear, they are not really human  brains.” At the time, she was able to recall 16 labs around the world  who had adopted her technique. But did she foresee that a year later, other labs would be injecting them into mouse brains? If neural networks  are at the root of consciousness and if we don’t fully understand how consciousness arises because of them, do we need to consider the ethical implications of producing brain organoids, which are becoming better and better at forming functional connections? The president of the Allen Institute for Brain Science in Seattle, Christof  Koch, has concerns, saying in an interview last year “We are entering totally new ground here. . . the science is advancing so rapidly, the ethics can’t keep up.”


Proceedings of the 9th Conference on Interdisciplinary Musicology – CIM14. Berlin, Germany 2014 BINAURAL AUDIO RELAXATION TECHNIQUES FOR PEOPLE WITH ANXIETY AND STRESS Geraldine Molina, Emilia Sainz, Levi Serrano, Santiago Rentería, Diana Urquiza Instituto Tecnológico y de Estudios Superiores de Monterrey, Campus Santa Fe Correspondence should be addressed to: rosas_ger@hotmail.com, dianauf@itesm.mx Abstract: Since the beginning of the 21st century, there has been a great development in different studies related to encephalography and the psychological consequences of binaural audio. The objective of this paper is to analyze the effects of binaural audio as a relaxation method for people that suffer anxiety and stress. The study took place at ITESM, Santa Fe Campus, where twenty participants around 21 years old took part of the study. They were divided into two groups, Experimental and Control. The first one listened to the Theta binaural stimuli and the second one listened to a stimulus with nature sounds (birds and wind). The results show that the experimental group got to conscious relaxation. The control group had an unconscious relaxation (sleep), but when the stimuli stopped they recovered their stress level, for some participants it increased. 1. BACKGROUND At the end of the 19th century, Pierre Janet, a French psychologist, discovered that his patients relaxed when they were exposed to rhythmic light patterns. Hans Berger showed in 1924 that brainwaves could be read and studied through an encephalogram [2]. The first studies were done using visual stimuli, while later studies were done using sounds [3]. Brainwaves are caused by changes in the electric tension between two points in the brain cortex. The electroencephalogram has been used to analyze neurophysiological relations that exist between mental states and brainwave frequencies. When somebody’s mental state changes from alert to somnolence, low amplitude and high frequency brain waves turn into high amplitude and low frequency [4]. 2. BINAURAL AUDIO Giuseppe Tartini discovered combination tones. These occur when two tones are heard at the same time and the listener perceives a third tone. The frequency of the third tone is calculated by the difference between the first two tones, as shown in equation 1. (∆   ) [8] (1) The superior olivary complex integrates the phase differences, which makes possible the perception of the third tone. For example, if the left ear hears a 400Hz tone and the right ear a 410Hz tone, the listener will perceive a 10Hz tone [9]. This third tone is also known as binaural frequency. The binaural frequency is directed from the superior olivary complex to the reticular formation and the brain cortex, where the electroencephalogram can read its effect. The Frequency Following Response (FFR) phenomenon happens when the frequency read by the encephalogram is equal to the combination tone frequency. When this happens, the frequency resonates in the brain stimulating the reticular formation inducing different psychological states. Brainwave bands and psychological consequences are shown in Table 1 [16]. Table 1: Brainwave Frequencies and Psychological Consequences Brainwaves Frequency (Hz) Amplitude (μV) Mental StateDelta 0.1 - 3 20-200 Consciousness is lost, sleep without dreams Theta 4 - 7 20-100 REM Sleep, meditation, and Creativity Alpha 8 - 12 20-60 Conscious Relaxation Beta 13 - 40 2-20 Concentration, Alert, and cognition (High levels are associated with anxiety) It has been proved that delta sound waves in binaural audio therapy have anxiolytic effects on patients with pre-surgery anxiety [7]. Theta binaural sound waves are also helpful with relaxation and anxiety reduction [11]. According to the results presented by the company Regus, in Mexico, 75% of employed people suffer from stress and anxiety. These cause social, health, and economic problems at the same time that productivity decreases [5]. According to the Mexican National Labor Organization, stress means that the GDP decreases from 0.5 to 3.5%. Stress leads to anxiety, irritability, fear, depression, suicidal thoughts, and lack of concentration. Some other symptoms are headaches, nausea, dizziness, muscular tension, insomnia, and tachycardia [6]. There are different techniques to induce relaxation like meditation. New relaxation techniques with binaural audio have been developed through Neurosciences. 3. OBJECTIVES • Evaluate and analyze binaural audio therapy effects (Theta frequencies) on people that suffer anxiety and stress (Students at ITESM), in order to induce relaxation and reduce anxiety. • Determine if the binaural therapy induced relaxation in the experimental group and compare the results to those from the control group. • Through the STAI test and the electroencephalogram results, determine which stimulus is more efficient. 4. HYPOTHESIS Hi: Frequency Following Response phenomenon will take place, as Delta and Theta bands will share frequencies with the combination tones. Hi: Beta brainwaves will show up when the stimulus begins, as they are related to concentration and alertness. 5. EXPERIMENT Twenty participants were randomly divided into two groups, control and experimental. The first group listened to sounds of

While a practical understanding of brainwaves has been around for as long as people have been singing, chanting, and drumming, a scientific view of the electrical activity inside the human brain was not published until 1924 when German psychiatrist Hans Berger developed a machine for sensing and recording activity in the brain by attaching small electrical sensors to the scalp of his patients and recording the resulting electrical activity. Berger’s inventions and discoveries were built upon the earlier work of Richard Caton who published animal studies on brainwave oscillations in 1875.


Winston and Maimes present the historical uses of these herbal remedies in India, Russia, China, and the Americas and explain how they work and why they are so effective at combating stress-induced illness. Monographs for each adaptogen also present the latest scientific research and include the origin, traditional use, actions, properties, preparation, and dosage for each herb.
Theta waves also have been observed in moments when a person recalls information from the past, and this may be what links them also to improvement in learning ability. We also experience theta waves when we go into automatic pilot mode, such as when doing a repetitive task like driving a familiar route where the mind become disconnected while you still drive safely toward your destination.
While originally brainwave entrainment was achieved by using pure tones of sound, it is now possible to take these tones and blend them with music, rhythms, and natural sounds, such as the sounds of flowing water, bird sounds, or waves lapping on a beach, creating extended tracts of varied and intriguing brainwave entrainment music for everyday use.
To further illustrate how brainwave entrainment enhances your meditation practice, here is an explanation. When an experienced and advanced meditator is hooked into equipment that reads their brainwave patterns, it is most common for their brain to move from whatever state they are in before they meditate (normally a Beta or higher Alpha state) slowly down into a deep Theta rhythm.  Very advanced meditators are able to bring their brain all the way into a Delta state, which is most normally where deep sleep occurs.  To be able to bring the brain into these deep brainwave states through the process of meditation can take years of meditative practice, and lots of discipline.
Our everyday, waking brain used for active intelligence operates at approximately 13 hertz, which is in the range of high alpha or low beta frequencies. People who have certain learning disabilities and problems with attention often have low levels of 13 hertz frequency brainwaves in crucial areas of the brain used for sequencing tasks and doing simple math calculations. This is one concrete example of how brainwaves are associated with thinking and behavior. Each identified brainwave frequency has a different effect on a person’s ability to think, act, and feel.
"I have been using Quantum Mind Power for two weeks and today I feel that although the changes are subtle, I have been able to overcome many roadblocks in my personal life. I have ADHD and have been taking Adderall for 7 years, recently I decided that I need to stop and have cut my dosage in half with the intention of completely stopping within a month.  I have also just started teaching Pilates as a second job.....
There's no doubt that brainwave entrainment audio is a great technology for anyone who is interested in encouraging altered states of consciousness and it certainly can help people to reach deeper states of relaxation than they might normally have access to. I myself will often listen to brainwave entrainment music in order to enhance my practice of meditation. But let’s keep a balanced perspective, put all the marketing hype to one side for a moment and acknowledge that there is no brainwave entrainment technology in this world that can make you meditate like a Zen monk “at the touch of a button”, despite what some might like you to believe. The mind is NOT a machine. It moves through various states of consciousness in an organic way and at a natural pace. We certainly can guide and accelerate that process with the use of brainwave entrainment audio, but we cannot control it with the same sort of specificity and immediacy as you might control the speed of the car you drive.
“Stress and sleepless nights are closely linked,” Buenaver says. “If you’re in pain, tend to worry, or are coping with a difficult situation in your life, you may have more stress hormones than usual circulating in your body. A poor night’s sleep adds even more. And those hormones may never be fully broken down. It’s like running an engine in fifth gear all the time.”
In the Omega Ruby & Alpha Sapphire chapter, Anabel and the other Hoenn Frontier Brains battle and defeat the Admins of Neo Team Magma and Neo Team Aqua, who had interfered in the launch of a rocket that was made to stop the meteoroid threatening to destroy the world. Once finished, Anabel is contacted by Emerald, who asks if any of the Frontier Brains had seen Sapphire in the area. When the Brains deny seeing Sapphire, Emerald thanks them and leaves. Later, Anabel and the other Hoenn Frontier Brains are called to Sootopolis City to assist in stopping the meteoroid.

Everyone experiences stress, and not all stress is bad. However, individuals who experience acute episodic and chronic stress are at increased risk for developing stress-related health problems. This article outlines the relationship between stress and health and discusses the role of exercise in managing stress. Exercise recommendations and stress management tips are provided.
“For two nights, I decided to use the Brain Salon's 'Deep Sleep' audio and it was sooo good! I fell asleep within seconds and felt refreshed upon waking the next few mornings. I recommended it to my father who has had trouble sleeping lately due to pain in his hands. He reported to the today that it helped him to not only fall asleep quicker but added an extra hour and a half of deep restful sleep - he loved it :)
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